Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9710078 | 0.90 | AGTR1 (0.43) | AGTR1TP53MEN1KMT2AMMP8 | |
| SCHEMBL9709619 | 0.86 | AGTR1 (0.44) | AGTR1TP53MEN1KMT2AMMP8 | |
| SCHEMBL9710053 | 0.85 | AGTR1 (0.46) | AGTR1TP53AGTR2 | |
| SCHEMBL9709506 | 0.84 | AGTR1 (0.46) | AGTR1TP53MEN1KMT2AAGTR2 | |
| SCHEMBL9316411 | 0.76 | AGTR1 (0.46) | AGTR1AGTR2MAPT | |
| SCHEMBL9538443 | 0.76 | AGTR1 (0.46) | AGTR1TSHRMAPK1 | |
| SCHEMBL9152304 | 0.75 | AGTR1 (0.42) | AGTR1TP53MEN1KMT2AAGTR2 | |
| SCHEMBL9057615 | 0.74 | AGTR1 (0.39) | AGTR1TSHR | |
| SCHEMBL4638349 | 0.74 | AGTR1 (0.47) | AGTR1MEN1KMT2ATSHRRAB9A | |
| SCHEMBL9154007 | 0.74 | AGTR1 (0.44) | AGTR1AGTR2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0507594-A1 | Substituted quinolines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-10-07 | — | — | EP | disclosed |