Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ACP1 | P24666 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709791 | 0.90 | LMNA (0.48) | LMNANPC1GUSBMAPTPOLB | |
| SCHEMBL9709841 | 0.86 | AGTR1 (0.43) | LMNAACP1 | |
| SCHEMBL3058746 | 0.84 | AGTR1 (0.50) | KMT2AACP1CYP2C19 | |
| SCHEMBL9315620 | 0.77 | AGTR1 (0.35) | — | |
| Hydrochloric Acid SCHEMBL9314540 | 0.76 | AGTR1 (0.34) | CYP2C19 | |
| SCHEMBL6635318 | 0.76 | AGTR1 (0.54) | — | |
| SCHEMBL31673809 | 0.75 | LMNA (0.73) | LMNANPC1GUSBMAPTPOLB | |
| SCHEMBL15101603 | 0.75 | LMNA (0.73) | LMNANPC1GUSBMAPTPOLB | |
| SCHEMBL7440794 | 0.75 | MEN1 (0.39) | LMNANPC1MAPTKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7840690 | 0.75 | AGTR1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | claimed |
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |