Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1879598 | 0.83 | KMT2A (0.46) | KMT2ATSHRPOLBCYP3A4TDP1 | |
| SCHEMBL9732893 | 0.79 | MAPT (0.39) | KMT2ATSHRCYP1A2MEN1ALDH1A1 | |
| SCHEMBL6670792 | 0.77 | CYP1A2 (0.53) | KMT2ATSHRPOLBCYP3A4TDP1 | |
| SCHEMBL9355150 | 0.75 | CYP1A2 (0.52) | KMT2ATSHRCYP3A4TDP1CYP1A2 | |
| SCHEMBL9355503 | 0.75 | CYP1A2 (0.52) | KMT2ATSHRCYP3A4TDP1CYP1A2 | |
| SCHEMBL9355058 | 0.75 | CYP1A2 (0.52) | KMT2ATSHRCYP3A4TDP1CYP1A2 | |
| SCHEMBL3052283 | 0.75 | CYP1A2 (0.52) | KMT2ATSHRCYP3A4TDP1CYP1A2 | |
| SCHEMBL8657397 | 0.75 | CYP1A2 (0.52) | KMT2ATSHRCYP3A4TDP1CYP1A2 | |
| SCHEMBL9351131 | 0.75 | CYP1A2 (0.52) | KMT2ATSHRCYP3A4TDP1CYP1A2 | |
| SCHEMBL9355489 | 0.75 | CYP1A2 (0.52) | KMT2ATSHRCYP3A4TDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0493324-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |