Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11580020 | 0.84 | GSTK1 (0.52) | MAPTABCC4CYP2D6NFKB1CYP2C19 | |
| SCHEMBL9709901 | 0.80 | SLC1A2 (0.38) | CYP2C19MEN1KMT2AALDH1A1SLC1A2 | |
| SCHEMBL10824781 | 0.80 | TSHR (0.50) | MAPTABCC4CYP2D6NFKB1CYP2C19 | |
| SCHEMBL9709877 | 0.79 | KMT2A (0.40) | TSHRMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9709564 | 0.77 | ALDH1A1 (0.38) | TSHRALDH1A1LMNA | |
| SCHEMBL9709906 | 0.76 | TSHR (0.34) | TSHR | |
| SCHEMBL9733201 | 0.75 | CYP1A2 (0.40) | MAPTCYP2D6NFKB1CYP2C19TSHR | |
| SCHEMBL11147230 | 0.74 | TSHR (0.45) | MAPTABCC4CYP2D6NFKB1CYP2C19 | |
| SCHEMBL5677958 | 0.74 | GRIK1 (0.46) | MAPTABCC4CYP2C19MEN1KMT2A | |
| SCHEMBL2359759 | 0.73 | TSHR (0.44) | MAPTABCC4CYP2D6NFKB1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |