Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423069 | 0.90 | LDHA (0.39) | MMP8ALDH1A1CYP2D6CYP2C19FFAR4 | |
| SCHEMBL9710075 | 0.79 | MMP8 (0.50) | MMP8SMN1; SMN2ALDH1A1CYP2C19TP53 | |
| SCHEMBL15261926 | 0.76 | SMN1; SMN2 (0.50) | MMP8SMN1; SMN2ALDH1A1TSHRALOX15 | |
| SCHEMBL9592711 | 0.75 | PPARG (0.46) | MMP8ALDH1A1TP53TDP1 | |
| SCHEMBL1522685 | 0.74 | MMP8 (0.64) | MMP8SMN1; SMN2EPHX2ALDH1A1TSHR | |
| SCHEMBL2425273 | 0.73 | MMP8 (0.46) | MMP8SMN1; SMN2ALDH1A1TSHRTP53 | |
| SCHEMBL17336471 | 0.71 | MMP8 (0.47) | MMP8SMN1; SMN2EPHX2ALDH1A1TSHR | |
| SCHEMBL15261460 | 0.71 | FFAR1 (0.43) | MMP8EPHX2 | |
| SCHEMBL9308568 | 0.70 | MAPT (0.52) | MMP8SMN1; SMN2ALDH1A1KDM4ERAB9A | |
| SCHEMBL2761376 | 0.70 | ALDH1A1 (0.35) | ALDH1A1CYP2D6CYP2C19FFAR4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158309-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158309-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-30 | — | — | WO | disclosed |