SCHEMBL9710619

SCHEMBL9710619

Cn1c(C#N)c(Cl)n(-c2ccccc2)c1=O

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 6/20 0.46
GSK3A P49840 5/20 0.46
PGR P06401 1/20 0.44
NPSR1 Q6W5P4 2/20 0.39
MAPK1 P28482 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 1/20 0.38
BCAT1 P54687 1/20 0.37
MAT2A P31153 1/20 0.36
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 2/20 0.35
RXFP1 Q9HBX9 1/20 0.35
GAA P10253 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9710787 0.87 GSK3A (0.49) GSK3BGSK3ANPSR1CYP1A2CYP2C9
SCHEMBL9710970 0.86 GSK3A (0.45) GSK3BGSK3ANPSR1MAPK1CYP1A2
SCHEMBL9710841 0.85 GSK3B (0.50) GSK3BGSK3APGRNPSR1MAPK1
SCHEMBL9710845 0.84 GSK3A (0.46) GSK3BGSK3AHPGDKDM4EALDH1A1
SCHEMBL9711118 0.81 MGLL (0.41) KDM4EALDH1A1GAAKMT2A
SCHEMBL9710731 0.81 GSK3A (0.50) GSK3BGSK3AGAA
SCHEMBL9710679 0.80 MAPT (0.41) ALDH1A1RXFP1KMT2A
SCHEMBL9710632 0.79 TDP2 (0.41) GSK3BGSK3ANPSR1HPGDBCAT1
SCHEMBL9710903 0.78 POLB (0.44) ALDH1A1
SCHEMBL9710822 0.75 GSK3A (0.50) GSK3BGSK3ANPSR1CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992021662-A1 POSSIBLY CONDENSED PHENYLIMIDAZOLONES AND PYRIMIDINONES AS HERBICIDES; INTERMEDIATES DOWELANCO (US) 1992-12-10 WO disclosed
US-5153316-A Post and preemergence herbicides DOWELANCO 1992-10-06 US disclosed