Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | BAX | Q07812 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537202 | 0.84 | LTA4H (0.50) | LTA4HSRD5A2EPHX2FAAHALDH1A1 | |
| SCHEMBL11089989 | 0.83 | CYP19A1 (0.50) | LTA4HSRD5A2GAAALDH1A1LMNA | |
| SCHEMBL1096270 | 0.79 | CES1 (0.55) | TSHRGAAKMT2AMEN1POLB | |
| SCHEMBL9252738 | 0.79 | LTA4H (0.61) | LTA4HSRD5A2FFAR1TSHRNR1H2 | |
| SCHEMBL1145770 | 0.79 | SRD5A2 (0.83) | LTA4HSRD5A2FFAR1TSHRNR3C1 | |
| SCHEMBL16755611 | 0.77 | LTA4H (0.69) | LTA4HSRD5A2FFAR1TSHRNR1H2 | |
| SCHEMBL1082295 | 0.77 | LTA4H (0.69) | LTA4HSRD5A2FFAR1TSHRNR1H2 | |
| SCHEMBL2273408 | 0.77 | ALDH1A1 (0.55) | LTA4HGAAKMT2APOLBCA1 | |
| SCHEMBL13673488 | 0.76 | LTA4H (0.57) | LTA4HSRD5A2FFAR1TSHRNR1H2 | |
| SCHEMBL850542 | 0.76 | SRD5A2 (0.62) | LTA4HSRD5A2FFAR1NR3C1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0304190-B1 | (ARYLSULPHONYL)NITROMETHANES, PROCESS FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-08 | — | — | EP | disclosed |
| EP-0304190-A1 | (Arylsulphonyl)nitromethanes, process for their preparation and use in pharmaceutical compositions | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-02-22 | — | — | EP | disclosed |