Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20171522 | 0.74 | LMNA (0.45) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL9515924 | 0.74 | LMNA (0.45) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL14564993 | 0.72 | LMNA (0.44) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL10859248 | 0.71 | LMNA (0.46) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL24548502 | 0.69 | LMNA (0.42) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL11163658 | 0.69 | TAAR1 (0.44) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL9740135 | 0.69 | TSHR (0.45) | TSHRCYP3A4SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL14273069 | 0.69 | LMNA (0.56) | LMNATSHRSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL9711236 | 0.69 | TDP1 (0.40) | LMNATSHRSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL10856259 | 0.68 | LMNA (0.41) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |