Prometon

Prometon

SCHEMBL9711318

COc1nc(N)nc(N(C(C)C)C(C)C)n1.COc1nc(NC(C)C)nc(NC(C)C)n1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.43
KMT2A Q03164 5/20 0.41
ALDH1A1 P00352 4/20 0.41
GAA P10253 3/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 3/20 0.41
CYP1A2 P05177 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
MAPT P10636 1/20 0.38
HTT P42858 4/20 0.37
TDP1 Q9NUW8 2/20 0.37
POLB P06746 1/20 0.36
TSHR P16473 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KCNH3 Q9ULD8 2/20 0.35
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4616571 0.86 TP53 (0.34) TP53ALDH1A1GAAL3MBTL1HTT
SCHEMBL14808678 0.83 HTT (0.47) TP53KMT2AALDH1A1GAAKDM4E
Prometon SCHEMBL22999 0.78 KMT2A (0.61) TP53KMT2AALDH1A1GAAKDM4E
Prometon SCHEMBL1517242 0.78 KMT2A (0.61) TP53KMT2AALDH1A1GAAKDM4E
SCHEMBL8057256 0.76 ALDH1A1 (0.61) KMT2AALDH1A1GAAKDM4EMEN1
SCHEMBL25766191 0.74 KMT2A (0.55) TP53KMT2AALDH1A1GAAKDM4E
SCHEMBL13759041 0.73 L3MBTL1 (0.41) TP53KMT2AALDH1A1GAAMEN1
SCHEMBL2682570 0.71 KMT2A (0.53) TP53KMT2AALDH1A1GAAKDM4E
SCHEMBL29462964 0.71 KMT2A (0.53) TP53KMT2AALDH1A1GAAKDM4E
SCHEMBL11109086 0.70 CYP1A2 (0.64) KMT2AALDH1A1GAAMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2691468-A1 COMPOSITIONS CONTAINING SULFONIC ACID CATALYSTS AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITIONS Dow Corning Corporation (US) 2014-02-05 EP disclosed
WO-2012134786-A1 COMPOSITIONS CONTINING SULFONIC ACID CATALYSTS AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITIONS DOW CORNING CORPORATION (US) 2012-10-04 WO disclosed
WO-1992020684-A1 HERBICIDAL OXATRICYCLIC ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-26 WO disclosed