SCHEMBL9711432

SCHEMBL9711432

O=C(O)COc1ccc2cc(Oc3c(Cl)cc(C(F)(F)F)c(F)c3Cl)ccc2c1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTPN7 P35236 1/20 0.46
THRB P10828 6/20 0.44
THRA P10827 5/20 0.44
MCL1 Q07820 2/20 0.43
AGER Q15109 1/20 0.43
PPARD Q03181 3/20 0.39
POLB P06746 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
TDP1 Q9NUW8 2/20 0.38
TSHR P16473 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 1/20 0.37
PPARA Q07869 1/20 0.37
PTGDR2 Q9Y5Y4 2/20 0.36
MRGPRX4 Q96LA9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9645027 0.98 PTPN7 (0.47) PTPN7THRBTHRAMCL1AGER
SCHEMBL9714352 0.91 POLB (0.38) PTPN7THRBTHRAAGERPOLB
SCHEMBL9711426 0.91 PTPN7 (0.48) PTPN7THRBTHRAMCL1AGER
SCHEMBL9711427 0.89 PDK2 (0.41) THRBTHRAMCL1PPARDTSHR
SCHEMBL9750969 0.89 POLB (0.37) PTPN7THRBTHRAPOLBMEN1
SCHEMBL9750924 0.89 PTPN7 (0.49) PTPN7THRBTHRAMCL1AGER
SCHEMBL9645082 0.87 THRB (0.40) PTPN7THRBTHRAMCL1PPARD
SCHEMBL9714089 0.84 THRB (0.37) THRBTHRAPOLBTDP1PPARA
SCHEMBL10482128 0.83 PLA2G7 (0.37) THRBTHRAKMT2ASMN1; SMN2
SCHEMBL9644881 0.83 THRB (0.36) THRBTHRAPOLBTDP1PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0315008-B1 DERIVATIVES OF (6-(HETERO)ARYLOXY-NAPHTHALIN-2-YL-OXY)ALCANOIC ACID BAYER AG (DE) 1992-09-09 EP disclosed
US-5079384-A Weed killers, destroy broad leaf plants, postemergence BAYER AKTIENGESELLSCHAFT (DE) 1992-01-07 US disclosed