SCHEMBL9714352

SCHEMBL9714352

O=C(Cl)COc1ccc2cc(Oc3c(Cl)cc(C(F)(F)F)c(F)c3Cl)ccc2c1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
THRB P10828 3/20 0.38
THRA P10827 2/20 0.38
PLA2G7 Q13093 8/20 0.36
PTPN7 P35236 1/20 0.35
MRGPRX4 Q96LA9 1/20 0.34
AGER Q15109 1/20 0.34
MAPT P10636 1/20 0.34
PTPRC P08575 1/20 0.34
PTPN1 P18031 1/20 0.34
PTPN11 Q06124 1/20 0.34
PTPN13 Q12923 1/20 0.34
PTPN22 Q9Y2R2 1/20 0.34
SCN9A Q15858 1/20 0.33
PARG Q86W56 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9750969 0.98 POLB (0.37) POLBTDP1THRBTHRAPLA2G7
SCHEMBL9711432 0.91 PTPN7 (0.46) POLBTDP1THRBTHRAPTPN7
SCHEMBL9645027 0.89 PTPN7 (0.47) POLBTDP1THRBTHRAPTPN7
SCHEMBL9714089 0.89 THRB (0.37) POLBTDP1THRBTHRAPLA2G7
SCHEMBL9644881 0.87 THRB (0.36) POLBTDP1THRBTHRAPLA2G7
SCHEMBL9711427 0.84 PDK2 (0.41) THRBTHRAMRGPRX4
SCHEMBL10482128 0.83 PLA2G7 (0.37) THRBTHRAPLA2G7MAPTALDH1A1
SCHEMBL9645082 0.83 THRB (0.40) THRBTHRAPTPN7
SCHEMBL10509974 0.81 PLA2G7 (0.36) THRBTHRAPLA2G7MAPTALDH1A1
SCHEMBL9711426 0.81 PTPN7 (0.48) POLBTDP1THRBTHRAPTPN7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5079384-A Weed killers, destroy broad leaf plants, postemergence BAYER AKTIENGESELLSCHAFT (DE) 1992-01-07 US disclosed