Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711974 | 0.86 | SMN1; SMN2 (0.44) | TDP1ALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL9712081 | 0.84 | PTPN1 (0.36) | PKMTDP1ALDH1A1TP53HPGD | |
| SCHEMBL9711755 | 0.84 | PTPN1 (0.34) | PKMTDP1ALDH1A1MAPTTP53 | |
| SCHEMBL9711750 | 0.84 | POLB (0.43) | TDP1ALDH1A1MAPTHPGDLMNA | |
| SCHEMBL9585643 | 0.83 | PKM (0.51) | PKMTDP1ALDH1A1MAPTTP53 | |
| SCHEMBL9711779 | 0.82 | PKM (0.42) | PKMTDP1ALDH1A1MAPTPPARG | |
| SCHEMBL9711860 | 0.81 | PKM (0.51) | PKMTDP1ALDH1A1MAPTTP53 | |
| SCHEMBL9711761 | 0.80 | HRH3 (0.41) | ALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL9585718 | 0.79 | PKM (0.56) | PKMTDP1ALDH1A1MAPTTP53 | |
| SCHEMBL9711805 | 0.78 | PKM (0.40) | PKMALDH1A1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303227-B1 | ETHERS AND THIOETHERS HAVING THERAPEUTICAL ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-02-05 | — | — | EP | disclosed |