Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | ICMT | O60725 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711803 | 0.87 | HTR1A (0.40) | ALDH1A1MAPTSLC22A6 | |
| SCHEMBL9711718 | 0.82 | PKM (0.49) | PKMPPARGALDH1A1MAPTTDP1 | |
| SCHEMBL9712066 | 0.82 | PPARG (0.39) | PKMACEICMTPPARGPPARA | |
| SCHEMBL9712088 | 0.79 | HTR1A (0.40) | ALDH1A1MAPT | |
| SCHEMBL9585643 | 0.78 | PKM (0.51) | PKMPPARGALDH1A1MAPTTDP1 | |
| SCHEMBL9711974 | 0.76 | SMN1; SMN2 (0.44) | ALDH1A1MAPTTDP1 | |
| SCHEMBL9585783 | 0.73 | PKM (0.53) | PKMPPARGALDH1A1MAPTTDP1 | |
| SCHEMBL9711860 | 0.71 | PKM (0.51) | PKMPPARGALDH1A1MAPTTDP1 | |
| SCHEMBL9585718 | 0.71 | PKM (0.56) | PKMPPARGALDH1A1MAPTTDP1 | |
| SCHEMBL4566374 | 0.71 | ACE (0.70) | ACEPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303227-B1 | ETHERS AND THIOETHERS HAVING THERAPEUTICAL ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-02-05 | — | — | EP | disclosed |