SCHEMBL9712158

SCHEMBL9712158

C[Si](C)(CBr)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.48
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
ALDH1A1 P00352 2/20 0.38
TSHR P16473 2/20 0.38
TRPA1 O75762 1/20 0.38
NR1H2 P55055 3/20 0.35
NR1H3 Q13133 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
MGAM O43451 2/20 0.34
TP53 P04637 1/20 0.32
PTPN1 P18031 1/20 0.31
GSK3B P49841 1/20 0.31
ELANE P08246 1/20 0.31
LMNA P02545 1/20 0.30
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9217667 0.78 MAPT (0.47) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL10389288 0.77 MAPT (0.38) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL7516560 0.77 CYP2A6 (0.40) MAPTALDH1A1GSK3B
SCHEMBL9226507 0.76 MAPT (0.45) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL7033371 0.75 MAPT (0.42) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL25284860 0.74 MAPT (0.44) MAPTESR1ESR2TSHRNR1H2
SCHEMBL852172 0.74 MAPT (0.44) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL3614652 0.74 MAPT (0.48) MAPTESR1ESR2ALDH1A1TSHR
SCHEMBL6833296 0.74 MAPT (0.44) MAPTESR1ESR2TSHRNR1H2
SCHEMBL18084487 0.74 MGAM (0.44) MAPTESR1ESR2TSHRNR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7164018-B2 Polymers based on N-carbamyl-N'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-01-16 US disclosed
WO-1992019622-A1 ARYLLITHIUM PROCESS FMC CORPORATION (US) 1992-11-12 WO disclosed
US-4971880-A MULTILAYER TONERS, DEVELOPERS, FOR ELECTROSTATIC LATENT IMAGES, CORES AND HALOGENATED CARBON PARTICLES MINOLTA CAMERA KABUSHIKI KAISHA (JP) 1990-11-20 US disclosed
US-4867541-A FILM FORMED BY PLASMA POLYMERIZATION OF PHTHALOCYANINE COMPOUND MINOLTA CAMERA KABUSHIKI KAISHA (JP) 1989-09-19 US disclosed
US-4828369-A ELECTROLYTES, PLASMA POLYMERIZATION OF HYDROCARBON, ALKALI METAL /COMPOUND/, ELECTRONEGATIVITY MINOLTA CAMERA KABUSHIKI KAISHA (JP) 1989-05-09 US disclosed
US-4801515-A Photosensitive member having an overcoat layer MINOLTA CAMERA KABUSHIKI KAISHA (JP) 1989-01-31 US disclosed
EP-0252442-A2 Photosensitive member having an overcoat layer Minolta Camera Kabushiki Kaisha (JP) 1988-01-13 EP disclosed