SCHEMBL852172

SCHEMBL852172

C[Si](C)(CCl)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.44
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
NR1H2 P55055 3/20 0.35
NR1H3 Q13133 3/20 0.35
MGAM O43451 2/20 0.34
ALDH1A1 P00352 2/20 0.33
LMNA P02545 2/20 0.33
TP53 P04637 1/20 0.32
KMT2A Q03164 1/20 0.31
TRPA1 O75762 1/20 0.31
MAPK1 P28482 1/20 0.31
GSK3B P49841 1/20 0.31
HIF1A Q16665 1/20 0.31
TSHR P16473 3/20 0.31
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30
CYP19A1 P11511 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8983921 0.86 CYP1A2 (0.41) MAPTESR1ESR2NR1H2NR1H3
SCHEMBL8755998 0.81 MAOA (0.38) ESR2ALDH1A1LMNA
SCHEMBL28024246 0.80 MAPT (0.41) MAPTESR1ESR2NR1H2NR1H3
SCHEMBL1270667 0.79 ESR1 (0.39) MAPTESR1ESR2NR1H2NR1H3
SCHEMBL9217667 0.78 MAPT (0.47) MAPTESR1ESR2NR1H2NR1H3
SCHEMBL15413402 0.77 ESR1 (0.38) MAPTESR1ESR2NR1H2NR1H3
SCHEMBL8755288 0.77 ACHE (0.40) MAPTALDH1A1LMNATP53ACHE
SCHEMBL10444591 0.77 ESR1 (0.38) MAPTESR1ESR2NR1H2NR1H3
SCHEMBL8983871 0.77 LMNA (0.40) ALDH1A1LMNAKMT2AGSK3B
SCHEMBL3228612 0.77 MGAM (0.43) MAPTESR1ESR2NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 241 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12306373-B2 Low melting point ionic liquids for infra-red liquid lens design CORNING INCORPORATED (US) 2025-05-20 US claimed
US-20240318001-A1 Thick Film Low Refractive Index Polysiloxane Claddings OPTITUNE OY (FI) 2024-09-26 US claimed
EP-4370588-A1 THICK FILM LOW REFRACTIVE INDEX POLYSILOXANE CLADDINGS Optitune Oy (FI) 2024-05-22 EP claimed
CN-113244761-B Mixed silicone oil for capturing acid gas through phase change and preparation method thereof 昆明理工大学 2023-07-07 CN claimed
WO-2023285739-A1 THICK FILM LOW REFRACTIVE INDEX POLYSILOXANE CLADDINGS OPTITUNE OY (FI) 2023-01-19 WO claimed
CN-113244761-A Mixed silicone oil for capturing acid gas through phase change and preparation method thereof 昆明理工大学 2021-08-13 CN claimed
CN-108905883-A A kind of preparation method of Si-C-Si type anionic organic silicon surfactant 九江学院 2018-11-30 CN claimed
CN-104788487-B A kind of hydrolysis Si C Si type cationic silicones surfactants 九江学院 2017-10-24 CN claimed
CN-104788487-A Hydrolysis resistant Si-C-Si type cation organosilicon surfactant UNIV JIUJIANG 2015-07-22 CN claimed
US-4278666-A FORMING KETOXIME SODIUM SALT, REACTING WITH TRIHYDROCARBYLCHLOROMETHYLSILANE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1981-07-14 US claimed
EP-0016375-A2 Novel silicon-containing oxime compounds, a method for their preparation, and anti-tumor agents containing the same Shin-Etsu Chemical Co., Ltd. (JP) 1980-10-01 EP claimed
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20250326936-A1 ARTICLES INCLUDING SURFACE COATINGS AND METHODS TO PRODUCE THEM MAXTERIAL INC (US) 2025-10-23 US disclosed
US-12306373-B2 Low melting point ionic liquids for infra-red liquid lens design CORNING INCORPORATED (US) 2025-05-20 US disclosed
EP-3769141-B1 TRANSMISSION RECOVERY AGENTS FOR LIQUID LENS FORMULATIONS CORNING INC (US) 2025-01-08 EP disclosed
US-4568760-A Process for the preparation of lactic acid silyl esters BAYER AKTIENGESELLSCHAFT (DE) 1986-02-04 US disclosed
EP-0068813-B1 FUNGICIDAL 1,2,4-TRIAZOLE AND IMIDAZOLE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-09-25 EP disclosed
US-4510136-A A 1-SILYLMETHYL DERIVATIVE; AGRICULTURE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-09 US disclosed
US-4278666-A FORMING KETOXIME SODIUM SALT, REACTING WITH TRIHYDROCARBYLCHLOROMETHYLSILANE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1981-07-14 US disclosed
EP-0016375-A2 Novel silicon-containing oxime compounds, a method for their preparation, and anti-tumor agents containing the same Shin-Etsu Chemical Co., Ltd. (JP) 1980-10-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR MAPT 4404/4885ESR1 2580/4885ESR2 1379/4885
US-12306373-B2 Low melting point ionic liquids for infra-red liquid lens design IK, CRYZ, CRYAA MAPT 132/4885ESR1 2862/4885ESR2 3177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.