Tetrahydrofuran

Tetrahydrofuran

SCHEMBL971242

C1CCOC1.OCCCCc1cccc2ccccc12

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 1/20 0.43
SCN5A Q14524 1/20 0.43
SIGMAR1 Q99720 3/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
MCL1 Q07820 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
TSHR P16473 1/20 0.42
HSD17B10 Q99714 1/20 0.42
PIK3CA P42336 2/20 0.41
PIK3CB P42338 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
SLC18A2 Q05940 1/20 0.40
MTNR1A P48039 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL971564 0.89 KCNA5 (0.46) KCNA5SCN5ASLC6A2SLC6A4KDM4E
SCHEMBL132272 0.87 KDM4E (0.51) SIGMAR1MCL1KDM4EALDH1A1GAA
SCHEMBL3262171 0.85 KDM4E (0.50) SIGMAR1MCL1KDM4EALDH1A1GAA
SCHEMBL129450 0.85 KDM4E (0.50) SIGMAR1MCL1KDM4EALDH1A1GAA
SCHEMBL12982187 0.85 KDM4E (0.50) SIGMAR1MCL1KDM4EALDH1A1GAA
SCHEMBL3905548 0.85 KDM4E (0.50) SIGMAR1MCL1KDM4EALDH1A1GAA
SCHEMBL12981741 0.85 KDM4E (0.50) SIGMAR1MCL1KDM4EALDH1A1GAA
SCHEMBL128594 0.85 KDM4E (0.50) SIGMAR1MCL1KDM4EALDH1A1GAA
Naphthalen-1-Yl-Methanol SCHEMBL971788 0.84 L3MBTL1 (0.47) KCNA5SCN5AKDM4EALDH1A1GAA
SCHEMBL31131331 0.82 MTNR1A (0.50) SIGMAR1MCL1KDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1829897-B1 SUPPORTED NON-METALLOCENE OLEFIN POLYMERIZATION CATALYST, AND PREPARATION AND USE THEREOF YANGZI PETROCHEMICAL COMPANY CO LTD (CN) 2014-12-10 EP disclosed
US-7875568-B2 reacting silica with titanium tetrachloride to obtain a modified carrier, then mixing with a solution of magnesium chloride, filtering, washing, suction and drying, to prepare a composite carriers, used as supports for addition polymerization catalysts, that improve polymer morphology and bulk density YANGZI PETROCHEMICAL COMPANY CO., LTD. (CN) 2011-01-25 US disclosed
US-20080227936-A1 reacting silica with titanium tetrachloride to obtain a modified carrier, then mixing with a solution of magnesium chloride, filtering, washing, suction and drying, to prepare a composite carriers, used as supports for addition polymerization catalysts, that improve polymer morphology and bulk density YANGZI PETROCHEMICAL COMPANY CO., LTD. (CN) 2008-09-18 US disclosed
EP-1829897-A1 SUPPORTED NON-METALLOCENE OLEFIN POLYMERIZATION CATALYST, AND PREPARATION AND USE THEREOF Yangzi Petrochemical Company Co., Ltd. (CN) 2007-09-05 EP disclosed