Tetrahydrofuran

Tetrahydrofuran

SCHEMBL971564

C1CCOC1.OCCc1cccc2ccccc12

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 1/20 0.46
SCN5A Q14524 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.43
SLC18A2 Q05940 1/20 0.43
MTNR1A P48039 2/20 0.43
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
ACP3 P15309 1/20 0.41
ABCB1 P08183 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL971242 0.89 KCNA5 (0.43) KCNA5SCN5AL3MBTL1SLC18A2MTNR1A
Naphthalen-1-Yl-Methanol SCHEMBL971788 0.88 L3MBTL1 (0.47) KCNA5SCN5AL3MBTL1SLC18A2TDP1
SCHEMBL27550 0.86 CYP1A2 (0.54) MTNR1ATDP1CYP1A2CYP2C9CYP2C19
Tetrahydrofuran SCHEMBL4655531 0.81 CYP4F2 (0.40) TDP1
Tetrahydrofuran SCHEMBL28098587 0.79 L3MBTL1 (0.46) KCNA5SCN5AL3MBTL1SLC18A2TDP1
Tetrahydrofuran SCHEMBL29135748 0.77 L3MBTL1 (0.43) KCNA5SCN5AL3MBTL1TDP1CYP1A2
SCHEMBL2312666 0.75 HPRT1 (0.54) MTNR1ATDP1CYP1A2CYP2C9CYP2C19
SCHEMBL2312926 0.75 HPRT1 (0.54) MTNR1ATDP1CYP1A2CYP2C9CYP2C19
Nitric Acid SCHEMBL9872877 0.75 ACP3 (0.50) L3MBTL1MTNR1ATDP1CYP1A2CYP2C9
Tetrahydrofuran SCHEMBL27878929 0.75 DPP4 (0.44) SLC6A2SLC6A4TDP1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1829897-B1 SUPPORTED NON-METALLOCENE OLEFIN POLYMERIZATION CATALYST, AND PREPARATION AND USE THEREOF YANGZI PETROCHEMICAL COMPANY CO LTD (CN) 2014-12-10 EP disclosed
US-7875568-B2 reacting silica with titanium tetrachloride to obtain a modified carrier, then mixing with a solution of magnesium chloride, filtering, washing, suction and drying, to prepare a composite carriers, used as supports for addition polymerization catalysts, that improve polymer morphology and bulk density YANGZI PETROCHEMICAL COMPANY CO., LTD. (CN) 2011-01-25 US disclosed
US-20080227936-A1 reacting silica with titanium tetrachloride to obtain a modified carrier, then mixing with a solution of magnesium chloride, filtering, washing, suction and drying, to prepare a composite carriers, used as supports for addition polymerization catalysts, that improve polymer morphology and bulk density YANGZI PETROCHEMICAL COMPANY CO., LTD. (CN) 2008-09-18 US disclosed
EP-1829897-A1 SUPPORTED NON-METALLOCENE OLEFIN POLYMERIZATION CATALYST, AND PREPARATION AND USE THEREOF Yangzi Petrochemical Company Co., Ltd. (CN) 2007-09-05 EP disclosed