Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | PLK1 | P53350 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10721101 | 0.86 | NR1H4 (0.59) | NR1H4PARP1PLK1THRBLMNA | |
| SCHEMBL29866996 | 0.84 | NR1H4 (0.58) | NR1H4PARP1CYSLTR2CYSLTR1 | |
| SCHEMBL9165641 | 0.80 | NR1H4 (0.73) | NR1H4PARP1PLK1THRBLMNA | |
| SCHEMBL9857033 | 0.80 | NR1H4 (0.63) | NR1H4THRBLMNASMN1; SMN2MEN1 | |
| SCHEMBL9160995 | 0.79 | NR1H4 (0.71) | NR1H4PARP1PLK1THRBLMNA | |
| SCHEMBL9713170 | 0.79 | NR1H4 (0.65) | NR1H4PARP1PLK1THRBLMNA | |
| SCHEMBL641663 | 0.77 | NR1H4 (0.62) | NR1H4PARP1PLK1THRBLMNA | |
| SCHEMBL9135604 | 0.77 | CACNA1H (0.49) | NR1H4PLK1CYSLTR2CYSLTR1 | |
| SCHEMBL9713817 | 0.76 | PLK1 (0.59) | PLK1CYSLTR2CYSLTR1 | |
| SCHEMBL9713307 | 0.76 | NR1H4 (0.76) | NR1H4PLK1THRBLMNASTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140046-A | Slow reacting substance of anaphylaxis antagonists | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0218728-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986005779-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-09 | — | — | WO | disclosed |