Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 4/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9160995 | 0.90 | NR1H4 (0.71) | NR1H4THRBMAPTTP53SMN1; SMN2 | |
| SCHEMBL9160169 | 0.87 | FAAH (0.55) | NR1H4SMN1; SMN2RAB9A | |
| SCHEMBL9713307 | 0.86 | NR1H4 (0.76) | NR1H4THRBMAPTTP53SMN1; SMN2 | |
| SCHEMBL9161294 | 0.85 | SMN1; SMN2 (0.64) | NR1H4MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL9163700 | 0.85 | NLRP3 (0.58) | NR1H4SMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL9713170 | 0.85 | NR1H4 (0.65) | NR1H4THRBMAPTTP53SMN1; SMN2 | |
| SCHEMBL9306724 | 0.84 | NR1H4 (0.77) | NR1H4MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL641663 | 0.83 | NR1H4 (0.62) | NR1H4THRBMAPTTP53SMN1; SMN2 | |
| SCHEMBL7828267 | 0.83 | NR1H4 (1.00) | NR1H4THRBMAPTTP53MEN1 | |
| SCHEMBL641423 | 0.83 | NR1H4 (0.71) | NR1H4THRBMAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432189-A | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5350759-A | Bis-aryl urea compounds | WISSNER ALLAN (US) | 1994-09-27 | — | — | US | disclosed |
| US-5231182-A | Platelet activating factor inhibitor | AMERICAN CYANAMID COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| US-5225425-A | Respiratory system disorders | AMERICAN CYANAMID COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5128351-A | BIS-ARYL AMIDE AND UREA ANTAGONISTS OF PLATELET ACTIVATING FACTOR | AMERICAN CYANAMID COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-5077409-A | Reducing hydroxy bis-aryl amide, acylating, hydrolyzing, sulfonating, halogenating, alkylating with nitrogen heterocycle | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0458037-A1 | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1991-11-27 | — | — | EP | disclosed |