Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | PLK1 | P53350 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713595 | 0.89 | NR1H4 (0.78) | NR1H4THRBMAPTSMN1; SMN2LMNA | |
| SCHEMBL8389461 | 0.88 | NR1H4 (0.65) | NR1H4THRBMEN1KMT2ANPC1 | |
| SCHEMBL9306724 | 0.86 | NR1H4 (0.77) | NR1H4PLK1TP53MAPTSMN1; SMN2 | |
| SCHEMBL9165641 | 0.86 | NR1H4 (0.73) | NR1H4THRBPLK1TP53MAPT | |
| SCHEMBL7828267 | 0.85 | NR1H4 (1.00) | NR1H4THRBTP53MAPTMEN1 | |
| SCHEMBL8389388 | 0.85 | KMT2A (0.59) | NR1H4THRBPLK1TP53MAPT | |
| SCHEMBL9160995 | 0.85 | NR1H4 (0.71) | NR1H4THRBPLK1TP53MAPT | |
| SCHEMBL641423 | 0.85 | NR1H4 (0.71) | NR1H4THRBPLK1TP53MAPT | |
| SCHEMBL8390958 | 0.85 | SMN1; SMN2 (0.67) | NR1H4PLK1TP53MAPTSMN1; SMN2 | |
| SCHEMBL8756930 | 0.85 | SMN1; SMN2 (0.67) | NR1H4PLK1TP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140046-A | Slow reacting substance of anaphylaxis antagonists | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0218728-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986005779-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-09 | — | — | WO | disclosed |