Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 3/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713372 | 0.93 | HTT (0.43) | HTTNCEH1ABCB11MAPTTNFSF11 | |
| SCHEMBL9642122 | 0.81 | ABCB11 (0.61) | HTTNCEH1ABCB11KDM4EGAA | |
| SCHEMBL28468360 | 0.77 | TOP1 (0.47) | HTTTOP1KDM4EGAAMAPT | |
| SCHEMBL9641756 | 0.76 | ABCB11 (0.52) | HTTNCEH1ABCB11KDM4EGAA | |
| SCHEMBL10522324 | 0.76 | ABCB11 (0.40) | HTTNCEH1ABCB11KDM4EGAA | |
| SCHEMBL7067974 | 0.76 | TSHR (0.53) | NCEH1TOP1KDM4EGAAALDH1A1 | |
| SCHEMBL7918996 | 0.76 | HTT (0.75) | HTTTOP1ABCB11KDM4EGAA | |
| SCHEMBL9713759 | 0.75 | HTT (0.48) | HTTTOP1ABCB11KDM4EGAA | |
| SCHEMBL9641670 | 0.73 | ABCB11 (0.52) | HTTNCEH1ABCB11KDM4EGAA | |
| SCHEMBL5780141 | 0.73 | MRGPRX4 (0.49) | HTTNCEH1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |