Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TOP1 | P11387 | 3/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918996 | 0.77 | HTT (0.75) | HTTTOP1ABCB11GAAKDM4E | |
| SCHEMBL9713986 | 0.76 | HTT (0.40) | HTTABCB11KMT2ATNFSF11ABCB1 | |
| SCHEMBL9713801 | 0.76 | ABCB11 (0.51) | HTTABCB11KDM4EMAPTTP53 | |
| SCHEMBL9713692 | 0.75 | HTT (0.47) | HTTTOP1ABCB11GAAKDM4E | |
| SCHEMBL9713982 | 0.74 | HTT (0.56) | HTTTOP1ABCB11GAAKDM4E | |
| SCHEMBL9627729 | 0.73 | TUBB4A (0.54) | HTTABCB11MAPTALDH1A1KMT2A | |
| SCHEMBL9627541 | 0.73 | HTT (0.51) | HTTABCB11GAAKDM4EMAPT | |
| SCHEMBL9713989 | 0.73 | BACE1 (0.40) | HTTABCB11GAAKDM4EMAPT | |
| SCHEMBL9713953 | 0.73 | HTT (0.42) | HTTABCB11GAAKDM4EMAPT | |
| SCHEMBL9713684 | 0.72 | ABCB11 (0.57) | HTTTOP1ABCB11GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |