Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.44 |
| ▸ | S100A4 | P26447 | 2/20 | 0.42 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | PTPRF | P10586 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15251827 | 0.87 | PTPN1 (0.55) | BACE1PTPN1S100A4PTPRCPTPRF | |
| SCHEMBL9713840 | 0.73 | S100A4 (0.44) | PTPN1S100A4CDC25BKMT2ACYP1A2 | |
| SCHEMBL10502584 | 0.73 | S100A4 (0.51) | S100A4KMT2AKDM4EHSP90AA1MEN1 | |
| SCHEMBL9713148 | 0.70 | S100A4 (0.40) | PTPN1S100A4KDM4EHSP90AA1RXFP1 | |
| SCHEMBL15821387 | 0.69 | S100A4 (0.50) | PTPN1S100A4PTPRCHSP90AA1PTPN11 | |
| SCHEMBL5050876 | 0.67 | CYP1A2 (0.52) | BACE1S100A4KMT2AKDM4ECYP1A2 | |
| SCHEMBL21887173 | 0.67 | BACE1 (0.70) | BACE1PTPN1PTPRCPTPRFCDC25B | |
| SCHEMBL15821909 | 0.67 | PTPN1 (0.42) | PTPN1S100A4PTPRCPTPRFCDC25B | |
| SCHEMBL23271777 | 0.66 | S100A4 (0.52) | PTPN1S100A4KMT2AKDM4EHSP90AA1 | |
| SCHEMBL21699234 | 0.66 | PTPN1 (0.44) | PTPN1S100A4PTPRCHSP90AA1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |