Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.48 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713850 | 0.83 | LMNA (0.43) | GAAKMT2AMEN1NR1H4LMNA | |
| SCHEMBL9713935 | 0.77 | PKM (0.67) | NPC1GAAKMT2AMEN1IDO1 | |
| SCHEMBL9714263 | 0.74 | PKM (0.60) | POLBGAAKMT2AMEN1IDO1 | |
| SCHEMBL4067862 | 0.72 | KMT2A (0.69) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL6814683 | 0.72 | MAPT (0.53) | POLBNPC1GAAKMT2AMEN1 | |
| SCHEMBL10891352 | 0.72 | PKM (0.56) | POLBNPC1GAAKMT2AMEN1 | |
| SCHEMBL9713891 | 0.71 | CNR2 (0.43) | NPC1GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4067788 | 0.71 | KMT2A (0.68) | GAAKMT2AMEN1ALDH1A1LMNA | |
| Bicarbonate SCHEMBL15226101 | 0.70 | KMT2A (0.66) | GAAKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9713815 | 0.70 | CNR1 (0.41) | POLBGAAALDH1A1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |