Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 0.65 |
| ▸ | MMP1 | P03956 | 10/20 | 0.63 |
| ▸ | MMP2 | P08253 | 8/20 | 0.63 |
| ▸ | MMP3 | P08254 | 6/20 | 0.63 |
| ▸ | TNF | P01375 | 2/20 | 0.63 |
| ▸ | MMP8 | P22894 | 6/20 | 0.62 |
| ▸ | MMP9 | P14780 | 5/20 | 0.62 |
| ▸ | MMP13 | P45452 | 4/20 | 0.62 |
| ▸ | MMP7 | P09237 | 3/20 | 0.58 |
| ▸ | MMP20 | O60882 | 1/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.58 |
| ▸ | MMP10 | P09238 | 1/20 | 0.58 |
| ▸ | MMP12 | P39900 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | MMP15 | P51511 | 1/20 | 0.58 |
| ▸ | MMP16 | P51512 | 1/20 | 0.58 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.58 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.58 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713877 | 0.81 | ADAM17 (0.51) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL9713883 | 0.81 | ADAM17 (0.51) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL9714084 | 0.81 | ADAM17 (0.76) | ADAM17MMP1MMP2MMP3TNF | |
| SCHEMBL9714151 | 0.78 | MMP1 (1.00) | ADAM17MMP1MMP2MMP3TNF | |
| SCHEMBL9714201 | 0.76 | ADAM17 (0.67) | ADAM17MMP1MMP2MMP3TNF | |
| Marimastat SCHEMBL34033 | 0.74 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3TNF | |
| Marimastat SCHEMBL134999 | 0.74 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3TNF | |
| Marimastat SCHEMBL17799241 | 0.74 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3TNF | |
| Marimastat SCHEMBL20793036 | 0.74 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3TNF | |
| Marimastat SCHEMBL8193003 | 0.74 | ADAM17 (1.00) | ADAM17MMP1MMP2MMP3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497192-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-08-05 | — | — | EP | disclosed |