Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641965 | 0.86 | LMNA (0.45) | ABCB11ATMLMNAMAPTKMT2A | |
| SCHEMBL9713719 | 0.84 | SMN1; SMN2 (0.43) | ABCB11ATMLMNAKMT2ATP53 | |
| SCHEMBL9642744 | 0.84 | ABCB11 (0.41) | ABCB11ATMLMNAMAPTGAA | |
| SCHEMBL9642055 | 0.81 | ABCB11 (0.47) | ABCB11LMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL9641934 | 0.80 | ABCB11 (0.44) | ABCB11ATMLMNAMAPTGAA | |
| SCHEMBL9643565 | 0.80 | ABCB11 (0.67) | ABCB11LMNAMAPTGAAPOLB | |
| SCHEMBL29372079 | 0.79 | ABCB11 (0.49) | ABCB11LMNAMAPTGAAPOLB | |
| SCHEMBL9642845 | 0.77 | ABCB11 (0.46) | ABCB11LMNAMAPTGAAKMT2A | |
| SCHEMBL9642881 | 0.77 | ABCB11 (0.52) | ABCB11LMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL9642687 | 0.77 | ABCB11 (0.52) | ABCB11LMNAMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |