Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 12/20 | 0.56 |
| ▸ | MMP2 | P08253 | 6/20 | 0.50 |
| ▸ | MMP3 | P08254 | 6/20 | 0.50 |
| ▸ | MMP1 | P03956 | 7/20 | 0.49 |
| ▸ | MMP13 | P45452 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713993 | 0.88 | ADAM17 (0.57) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL9714002 | 0.88 | ADAM17 (0.57) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL9714100 | 0.88 | ADAM17 (0.59) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL9713913 | 0.88 | ADAM17 (0.59) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL9713883 | 0.85 | ADAM17 (0.51) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL9713877 | 0.85 | ADAM17 (0.51) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL4635106 | 0.79 | ADAM17 (0.61) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL4635111 | 0.79 | ADAM17 (0.61) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL9713814 | 0.79 | MMP2 (0.60) | ADAM17MMP2MMP3MMP1MMP13 | |
| SCHEMBL4634157 | 0.79 | MMP2 (0.60) | ADAM17MMP2MMP3MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497192-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-08-05 | — | — | EP | disclosed |