Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 0.61 |
| ▸ | MMP1 | P03956 | 9/20 | 0.53 |
| ▸ | MMP13 | P45452 | 4/20 | 0.53 |
| ▸ | MMP2 | P08253 | 6/20 | 0.52 |
| ▸ | MMP3 | P08254 | 5/20 | 0.52 |
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | MMP8 | P22894 | 4/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 2/20 | 0.51 |
| ▸ | MMP20 | O60882 | 1/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | MMP10 | P09238 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | MMP15 | P51511 | 1/20 | 0.51 |
| ▸ | MMP16 | P51512 | 1/20 | 0.51 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.51 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635111 | 1.00 | ADAM17 (0.61) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL9714002 | 0.87 | ADAM17 (0.57) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL9713993 | 0.87 | ADAM17 (0.57) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL7372918 | 0.86 | MMP2 (0.48) | ADAM17MMP2MMP3 | |
| SCHEMBL9714100 | 0.83 | ADAM17 (0.59) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL9713913 | 0.83 | ADAM17 (0.59) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL7392184 | 0.81 | MMP1 (0.53) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL8015876 | 0.81 | ADAM17 (0.52) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL7444240 | 0.80 | MMP1 (0.49) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL8649599 | 0.80 | MMP2 (0.54) | MMP1MMP13MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931624-A1 | USE OF AN AUREOLYSIN INHIBITOR FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS CHARACTERISED BY COLONISATION WITH STAPHYLOCOCCUS AUREUS | Serentis Limited (GB) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007025999-A1 | USE OF AN AUREOLYSIN INHIBITOR FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS CHARACTERISED BY COLONISATION WITH STAPHYLOCOCCUS AUREUS | SERENTIS LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049518-A1 | Novel method of treatment of inflammatory skin conditions | SERENTIS LIMITED (GB) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049518-A1 | Novel method of treatment of inflammatory skin conditions | MMP8, CUTA, MMP1 | ADAM17 192/4885MMP1 3/4885MMP13 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.