SCHEMBL9714610

SCHEMBL9714610

N#Cc1ccc(CCl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.46
MAOA P21397 5/20 0.46
TSHR P16473 1/20 0.45
MAPT P10636 1/20 0.44
CYP3A4 P08684 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
LOXL2 Q9Y4K0 2/20 0.42
CYP2A6 P11509 1/20 0.42
CYP19A1 P11511 2/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
GAA P10253 1/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
CA12 O43570 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15657685 0.82 TSHR (0.59) MAOBMAOATSHRMAPTCYP3A4
SCHEMBL15657161 0.82 TSHR (0.59) MAOBMAOATSHRMAPTCYP3A4
SCHEMBL22871613 0.82 CYP3A4 (0.57) TSHRCYP3A4TDP1CYP19A1SMN1; SMN2
SCHEMBL200142 0.82 LOXL2 (0.58) MAOBMAOATSHRLOXL2CYP2A6
SCHEMBL9432333 0.82 MAOB (0.46) MAOBMAOATSHRMAPTCYP3A4
SCHEMBL9714604 0.82 TDP1 (0.43) MAOBMAPTCYP3A4TDP1NPC1
SCHEMBL9714736 0.81 MAOA (0.42) MAOBMAOATSHRCYP3A4TDP1
Hydrochloric Acid SCHEMBL5143704 0.81 CYP3A4 (0.55) MAOBMAOATSHRCYP3A4TDP1
(Chloromethyl)Benzene SCHEMBL304085 0.80 CYP3A4 (0.60) TSHRCYP3A4TDP1LOXL2CYP19A1
SCHEMBL11799900 0.79 MAOB (0.52) MAOBMAOATSHRMAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5166210-A QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1992-11-24 US disclosed
US-5028615-A Treatment of hypersensitivity RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1991-07-02 US disclosed