Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9161636 | 0.93 | LOXL2 (0.54) | LOXL2CYP2A6CYP19A1MAOBMAOA | |
| SCHEMBL2899550 | 0.93 | LOXL2 (0.52) | LOXL2CYP2A6CYP19A1MAOBMAOA | |
| SCHEMBL2999573 | 0.87 | PARP15 (0.49) | LOXL2CYP2A6CYP19A1MAOBMAOA | |
| SCHEMBL9714610 | 0.82 | MAOB (0.46) | LOXL2CYP2A6CYP19A1MAOBMAOA | |
| SCHEMBL27524812 | 0.80 | CA1 (0.48) | LOXL2CYP2A6CYP19A1ALDH1A1CA2 | |
| SCHEMBL7523258 | 0.80 | LOXL2 (0.54) | LOXL2CYP2A6CYP19A1MAOBMAOA | |
| SCHEMBL1344068 | 0.78 | LOXL2 (0.65) | LOXL2CYP2A6CYP19A1MAOBMAOA | |
| SCHEMBL1004267 | 0.78 | LOXL2 (0.64) | LOXL2CYP2A6CYP19A1MAOBMAOA | |
| SCHEMBL27707919 | 0.77 | LOXL2 (0.56) | LOXL2CYP2A6CYP19A1KCNJ1KCNH2 | |
| SCHEMBL45942 | 0.76 | CA2 (0.69) | LOXL2CYP2A6MAOBMAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 870 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119708044-A | Andrographolide derivative containing thiazolidine ketone heterocycle, preparation method and application thereof | 西北农林科技大学 | 2025-03-28 | — | — | CN | claimed |
| CN-118258909-A | Method for measuring content of p-cyanobenzyl chloride and isomers thereof in letrozole | 河北以岭医药研究院有限公司 | 2024-06-28 | — | — | CN | claimed |
| CN-115677533-B | Preparation method of 4-heptyl benzonitrile | 沈阳化工研究院有限公司 | 2023-12-05 | — | — | CN | claimed |
| CN-115677533-A | Preparation method of 4-heptyl cyanobenzene | 沈阳化工研究院有限公司 | 2023-02-03 | — | — | CN | claimed |
| CN-110540526-B | Carane acidyl 1,2, 3-triazole compound and preparation method and application thereof | 广西大学 | 2022-08-30 | — | — | CN | claimed |
| CN-113880780-A | Benzamidine derivative, preparation method and application thereof | 西北农林科技大学 | 2022-01-04 | — | — | CN | claimed |
| CN-112281218-A | Electron transfer type photochromic crystal material and preparation method and application thereof | 山西师范大学 | 2021-01-29 | — | — | CN | claimed |
| US-20200291222-A1 | ORGANOPHOSPHORUS FLAME-RETARDANT TETRAZINES | INTERNATIONAL BUSINESS MACHINES CORPORATION | 2020-09-17 | — | — | US | claimed |
| CN-106558534-B | Structure and method for interconnection | 台湾积体电路制造股份有限公司 | 2020-07-31 | — | — | CN | claimed |
| CN-107988811-B | Flame-retardant polyurethane synthetic leather | 佛山市艾菲特自行车配件有限公司 | 2020-06-05 | — | — | CN | claimed |
| EP-1871750-A1 | IMPROVED PROCESS FOR THE PREPARATION OF LETROZOLE | Sicor, Inc. (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2007107733-A1 | SYNTHESIS OF 4-[1-(4-CYANO PHENYL)-(1,2,4-TR1AZOL-1-YL)METHYL] BENZONITRILE AND 4-[1-(1H-1,2,4-TRIAZOL-1-YL)METHYLENE BENZONITRILE INTERMEDIATE | CIPLA LIMITED (IN) | 2007-09-27 | — | — | WO | claimed |
| WO-2007100346-A1 | IMPROVED PROCESS FOR THE PREPARATION OF LETROZOLE | SICOR, INC. (US) | 2007-09-07 | — | — | WO | claimed |
| US-20070066831-A1 | Process for the preparation of letrozole | SICOR, INC. | 2007-03-22 | — | — | US | claimed |
| EP-1004574-B1 | Process for producing cyanobenzyl compounds | SHOWA DENKO KK (JP) | 2003-03-19 | — | — | EP | claimed |
| US-6187945-B1 | TRANSFORMING AN AMINOMETHYL GROUP OF A CYANOBENZYLAMINE COMPOUND INTO A HYDROXYMETHYL GROUP, A HALOMETHYL GROUP, OR AN ACYLOXYMETHYL GROUP BY DIAZOTIZATION AND HYDROXYLATION, HALOGENATION OR ACYLATION | SHOWA DENKO K.K. (JP) | 2001-02-13 | — | — | US | claimed |
| EP-1004574-A1 | Process for producing cyanobenzyl compounds | Showa Denko Kabushiki Kaisha (JP) | 2000-05-31 | — | — | EP | claimed |
| EP-0123906-B1 | METHOD FOR THE PREPARATION OF STILBENE DICARBONITRILES | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-05-06 | — | — | EP | claimed |
| US-4519953-A | DIMERIZING CYANOBENZYL CHLORIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-05-28 | — | — | US | claimed |
| EP-0093443-B1 | ALKYL ESTER IMINES OF HALOMETHYL BENZOIC ACIDS AND PROCESSES FOR THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-03 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066831-A1 | Process for the preparation of letrozole | CYP19A1, CYP4B1, CYP3A4 | LOXL2 4675/4885CYP2A6 163/4885CYP19A1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.