Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.45 |
| ▸ | SNCA | P37840 | 2/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714497 | 0.96 | SNCA (0.44) | CHRNA7SNCAKCNA3 | |
| Hydrochloric Acid SCHEMBL3091790 | 0.88 | KCNA3 (0.55) | CHRNA7SNCAKCNA3L3MBTL1HDAC3 | |
| Bromide SCHEMBL9336662 | 0.85 | KCNA3 (0.55) | CHRNA7SNCAKCNA3L3MBTL1HDAC3 | |
| Hydrochloric Acid SCHEMBL3102838 | 0.82 | FFAR1 (0.56) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL1046793 | 0.82 | LTA4H (0.54) | CHRNA7SNCA | |
| Hydrochloric Acid SCHEMBL9714808 | 0.81 | GUSB (0.39) | — | |
| Hydrochloric Acid SCHEMBL9714606 | 0.80 | SNCA (0.49) | SNCAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL9714793 | 0.80 | CHRNA7 (0.40) | CHRNA7SNCASLC2A1 | |
| SCHEMBL11799195 | 0.79 | KCNA3 (0.67) | KCNA3LTB4RHDAC3HDAC4HDAC1 | |
| Iodide SCHEMBL1047429 | 0.79 | LTA4H (0.54) | CHRNA7SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |