Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714652 | 0.87 | MEN1 (0.37) | SNCAHIF1APOLBCTSCOPRK1 | |
| Hydrochloric Acid SCHEMBL9714489 | 0.86 | SNCA (0.49) | SNCAHIF1AMAOBTSHRSIGMAR1 | |
| Hydrochloric Acid SCHEMBL9714793 | 0.82 | CHRNA7 (0.40) | SNCASIGMAR1 | |
| SCHEMBL13900603 | 0.82 | POLB (0.47) | POLBCTSCOPRK1KDM4ETSHR | |
| Hydrochloric Acid SCHEMBL9714780 | 0.78 | SNCA (0.50) | SNCAHIF1AMAOBTSHR | |
| Hydrochloric Acid SCHEMBL9714606 | 0.76 | SNCA (0.49) | SNCAHIF1AMAOBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL2446696 | 0.76 | SNCA (0.69) | SNCAHIF1ATSHRSIGMAR1 | |
| Hydrochloric Acid SCHEMBL9714819 | 0.76 | SNCA (0.38) | SNCAHIF1AMAOBSIGMAR1 | |
| Bromide SCHEMBL6849936 | 0.75 | HIF1A (0.58) | SNCAHIF1AMAOBTSHR | |
| Hydrochloric Acid SCHEMBL9714711 | 0.74 | SNCA (0.46) | SNCAHIF1ACTSCMAOBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |