Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714819 | 0.86 | SNCA (0.38) | SNCAMAOBHIF1ATAAR1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9714833 | 0.86 | SNCA (0.45) | SNCAMAOBHIF1ASIGMAR1TSHR | |
| SCHEMBL13593628 | 0.82 | SIGMAR1 (0.52) | MAOBTAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL1752148 | 0.82 | SIGMAR1 (0.52) | MAOBTAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL14452762 | 0.82 | SIGMAR1 (0.52) | MAOBTAAR1SIGMAR1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9714711 | 0.81 | SNCA (0.46) | SNCAMAOBHIF1ATAAR1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9714793 | 0.80 | CHRNA7 (0.40) | SNCASIGMAR1 | |
| Hydrochloric Acid SCHEMBL2446696 | 0.80 | SNCA (0.69) | SNCAHIF1ATAAR1SIGMAR1SLC6A2 | |
| SCHEMBL8763089 | 0.80 | ESR2 (0.42) | MAOBTAAR1SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL10322372 | 0.79 | CTSK (0.47) | MAOBTAAR1SIGMAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |