Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 2/20 | 0.46 |
| ▸ | CTSC | P53634 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714788 | 0.87 | CTSB (0.37) | SNCACTSCCTSKHIF1ACTSS | |
| SCHEMBL31118140 | 0.83 | CTSC (0.46) | CTSCCTSKCYP2D6TRPA1MAOB | |
| Hydrochloric Acid SCHEMBL9714489 | 0.81 | SNCA (0.49) | SNCACYP3A4CYP1A2CYP2D6HIF1A | |
| Hydrochloric Acid SCHEMBL2446696 | 0.77 | SNCA (0.69) | SNCACYP3A4CYP1A2CYP2D6HIF1A | |
| Hydrochloric Acid SCHEMBL1539229 | 0.76 | SNCA (0.58) | SNCACYP3A4CYP1A2CYP2D6HIF1A | |
| Hydrochloric Acid SCHEMBL9714608 | 0.75 | SNCA (0.53) | SNCACYP3A4CYP1A2CYP2D6HIF1A | |
| Hydrochloric Acid SCHEMBL1575597 | 0.75 | SNCA (0.53) | SNCAHIF1AMAOBMAOA | |
| Bromide SCHEMBL28174352 | 0.74 | SNCA (0.55) | SNCACYP3A4CYP1A2HIF1ATRPA1 | |
| Hydrochloric Acid SCHEMBL9714833 | 0.74 | SNCA (0.45) | SNCACTSCHIF1AMAOBSIGMAR1 | |
| Bromide SCHEMBL39844 | 0.73 | SNCA (0.73) | SNCACYP3A4CYP1A2CYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |