Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10997007 | 0.89 | SLC6A3 (0.52) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30434109 | 0.79 | CYP1A2 (0.45) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30434010 | 0.79 | CYP1A2 (0.45) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8693156 | 0.78 | CYP1A2 (0.39) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7382538 | 0.78 | SLC6A3 (0.49) | SLC6A3TSHRALDH1A1LMNAMAPT | |
| SCHEMBL13934689 | 0.78 | TRPA1 (0.44) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7959062 | 0.77 | SLC6A3 (0.63) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17429837 | 0.77 | SLC6A3 (0.63) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16011833 | 0.77 | SLC6A3 (0.63) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7439094 | 0.77 | SLC6A3 (1.00) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11555013-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE USA, AS REPRESENTED BY THE SECRETARY, DHHS (US) | 2023-01-17 | — | — | US | disclosed |
| EP-2964611-B1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | US HEALTH (US) | 2022-10-19 | — | — | EP | disclosed |
| EP-2964611-B1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | US HEALTH (US) | 2022-10-19 | — | — | EP | disclosed |
| US-20210130288-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-05-06 | — | — | US | disclosed |
| US-20210130288-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-05-06 | — | — | US | disclosed |
| US-10913711-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-02-09 | — | — | US | disclosed |
| US-10913711-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-02-09 | — | — | US | disclosed |
| US-10590074-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-03-17 | — | — | US | disclosed |
| US-10590074-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185424-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2019-06-20 | — | — | US | disclosed |
| US-20160009644-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | The United States of America, as represented by th Secretary, Department of Health and Human Service (US) | 2016-01-14 | — | — | US | disclosed |
| EP-2964611-A2 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | The United States of America, as represented by The Secretary, Department of Health and Human Services (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014138518-A2 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2014-09-12 | — | — | WO | disclosed |
| US-5116988-A | Antiepileptic | WARNER-LAMBERT CO. (US) | 1992-05-26 | — | — | US | disclosed |
| US-5053521-A | 3-amino butyric acid uptake inhibitors, antiepileptic agents | WARNER-LAMBERT COMPANY (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0221572-B1 | N-SUBSTITUTED 3-PIPERIDINE-OR 3-PYRIDINE-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-09-25 | — | — | EP | disclosed |
| US-4910312-A | Containing 1-(2-(bis((4-trifluoromethylphenyl)methoxy)-ethyl)-substitution | WARNER-LAMBERT COMPANY (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0346927-A2 | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridine-carboxylic acids and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4772615-A | ANTICONVULSANT FOR TREATING EPILEPSY | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0221572-A2 | N-substituted 3-piperidine-or 3-pyridine-carboxylic acids and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185424-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885CYP1A2 580/4885CYP3A4 367/4885 |
| US-10590074-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885CYP1A2 580/4885CYP3A4 367/4885 |
| US-20210130288-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885CYP1A2 580/4885CYP3A4 367/4885 |
| US-20160009644-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885CYP1A2 580/4885CYP3A4 367/4885 |
| US-11555013-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885CYP1A2 580/4885CYP3A4 367/4885 |
| US-10913711-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885CYP1A2 580/4885CYP3A4 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.