Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714935 | 0.87 | L3MBTL1 (0.44) | MEN1KMT2ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL9714993 | 0.85 | KMT2A (0.47) | TDP1MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL28363369 | 0.81 | KMT2A (0.47) | MEN1KMT2ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL12593806 | 0.80 | TDP1 (0.47) | TDP1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL7457651 | 0.77 | SMN1; SMN2 (0.47) | TDP1MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL16624908 | 0.73 | KCNA5 (0.53) | TDP1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL7768899 | 0.72 | PDPK1 (0.57) | TDP1MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL29174147 | 0.72 | MAPT (0.46) | TDP1L3MBTL1HPGDALDH1A1MAPT | |
| SCHEMBL11471490 | 0.71 | L3MBTL1 (0.46) | SMN1; SMN2L3MBTL1HPGDALDH1A1MAPT | |
| SCHEMBL1201267 | 0.71 | NPC1 (0.62) | TDP1MEN1KMT2ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992018484-A1 | 3-AMINO-5-ARYLPYRAZOLE-4-ACETIC ACID DERIVATIVES EXHIBITING THERAPEUTIC EFFECTS | A.H. ROBINS COMPANY, INCORPORATED (US) | 1992-10-29 | — | — | WO | disclosed |
| US-5114944-A | Anxiolytic and anticonvulsant agents; muscle relaxants | A. H. ROBINS COMPANY INCORPORATED (US) | 1992-05-19 | — | — | US | disclosed |
| US-5057534-A | Anxiolytic, anticonfulsant and muscle relaxants | A. H. ROBINS COMPANY INCORPORATED (US) | 1991-10-15 | — | — | US | disclosed |