Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9649781 | 0.86 | KDM4E (0.44) | TSHRALDH1A1TDP1SMN1; SMN2KDM4E | |
| SCHEMBL9650664 | 0.82 | SMN1; SMN2 (0.40) | L3MBTL1TSHRALDH1A1MAPK1TDP1 | |
| SCHEMBL9650914 | 0.80 | KMT2A (0.46) | L3MBTL1TSHRALDH1A1MAPK1TDP1 | |
| SCHEMBL9647401 | 0.78 | TDP1 (0.45) | L3MBTL1TSHRALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL9649751 | 0.77 | TSHR (0.42) | L3MBTL1TSHRALDH1A1MAPK1TDP1 | |
| SCHEMBL9650272 | 0.76 | LMNA (0.44) | TSHRALDH1A1TDP1SMN1; SMN2NPC1 | |
| SCHEMBL9647521 | 0.76 | KCNK3 (0.39) | TSHRALDH1A1MAPK1TDP1KDM4E | |
| SCHEMBL9647321 | 0.72 | MEN1 (0.49) | ALDH1A1MAPK1TDP1SMN1; SMN2NPC1 | |
| SCHEMBL27504359 | 0.71 | NLRP3 (0.41) | L3MBTL1TSHRALDH1A1MAPK1TDP1 | |
| SCHEMBL1825614 | 0.70 | LMNA (0.43) | L3MBTL1ALDH1A1MAPK1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266980-B1 | PHARMACEUTICAL COMPOSITIONS, COMPRISING A 2,4-DIPHENYL-1,3-DIOXANE DERIVATIVE AND AN INHIBITOR OF THROMBOXANE A2 SYNTHESIS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-28 | — | — | EP | disclosed |
| EP-0201354-B1 | 2,4-DIPHENYL-1,3-DIOXANES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-09-19 | — | — | EP | disclosed |
| US-4908380-A | Substituted 1,3-dioxane ether derivative; thromboxane A2 inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-13 | — | — | US | disclosed |
| US-4895962-A | THROMBOXANE A2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-01-23 | — | — | US | disclosed |
| US-4775685-A | THROMBOXANE A-2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-10-04 | — | — | US | disclosed |
| EP-0201354-A2 | 2,4-Diphenyl-1,3-Dioxanes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-11-12 | — | — | EP | disclosed |