Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12081257 | 0.90 | HTR2C (0.47) | EEDMGAMAMY1AGAASI | |
| SCHEMBL8548879 | 0.78 | ADRB1 (0.50) | HTR2CHTR1A | |
| Methylamine SCHEMBL27464902 | 0.77 | MGAM (0.49) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL22040163 | 0.72 | EED (0.48) | EEDMGAMAMY1AGAASI | |
| SCHEMBL28533805 | 0.70 | HTR2C (0.57) | CHRNB4CHRNA3HTR2CHTR1A | |
| SCHEMBL1781998 | 0.70 | TP53 (0.47) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL6782222 | 0.69 | ABCG2 (0.43) | EEDMGAMAMY1AGAASI | |
| SCHEMBL1663468 | 0.69 | HTR2C (0.43) | CHRNB4CHRNA3HTR2C | |
| SCHEMBL13584700 | 0.68 | ABCG2 (0.46) | EEDMGAMAMY1AGAASI | |
| SCHEMBL28784844 | 0.68 | MGAM (0.44) | EEDMGAMAMY1AGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140040-A | Alpha-2-adrenergic receptor antagonist; glaucoma; congestive heart failure; hypotensive agents; headaches; metabolic disorders (diabetes, obesity) | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5128362-A | Antidepressant, antiglaucoma | ABBOTT LABORATORIES (US) | 1992-07-07 | — | — | US | disclosed |
| US-5086074-A | Selective adrenergic receptor antagonists | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |