Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10473121 | 0.83 | SMN1; SMN2 (0.57) | DHFREGFRPLAUKDM4EHSD17B10 | |
| Oxalic Acid SCHEMBL9536039 | 0.82 | KDM4E (0.66) | DHFREGFRPLAUKDM4EUSP2 | |
| SCHEMBL9536249 | 0.77 | KDM4E (0.53) | DHFREGFRPLAUKDM4EUSP2 | |
| SCHEMBL9537766 | 0.75 | NPC1 (0.61) | PLAUKDM4EALOX15HSD17B10NPC1 | |
| SCHEMBL12894447 | 0.74 | PLAU (0.46) | DHFREGFRPLAUKDM4EUSP2 | |
| SCHEMBL2215321 | 0.73 | HRH3 (0.61) | DHFREGFRL3MBTL1KDM4EUSP2 | |
| SCHEMBL725129 | 0.71 | PLA2G4A (0.57) | L3MBTL1NPC1POLB | |
| SCHEMBL10278061 | 0.71 | L3MBTL1 (0.54) | L3MBTL1KDM4EPIK3CGNPC1POLB | |
| SCHEMBL25083597 | 0.71 | L3MBTL1 (0.62) | L3MBTL1KDM4EALOX15HSD17B10NPC1 | |
| SCHEMBL28305604 | 0.71 | L3MBTL1 (0.47) | DHFREGFRL3MBTL1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343893-B1 | AROMATIC AND HETEROCYCLIC CARBOXAMIDE DERIVATIVES AS ANTINEOPLASTIC AGENTS | PFIZER INC. (US) | 1992-08-05 | — | — | EP | disclosed |