Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | FPR3 | P25089 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536249 | 0.92 | KDM4E (0.53) | KDM4EUSP2ALOX15HSD17B10FPR3 | |
| SCHEMBL9715442 | 0.82 | DHFR (0.50) | KDM4EUSP2ALOX15HSD17B10FPR3 | |
| SCHEMBL13763209 | 0.79 | PIK3CG (0.56) | KDM4EHSD17B10ALDH1A1PLAUPIK3CG | |
| SCHEMBL10473121 | 0.78 | SMN1; SMN2 (0.57) | KDM4EHSD17B10ALDH1A1PLAURAB9A | |
| SCHEMBL12894447 | 0.75 | PLAU (0.46) | KDM4EUSP2ALOX15HSD17B10PLAU | |
| SCHEMBL4532805 | 0.73 | PIK3CG (0.82) | KDM4EHSD17B10ALDH1A1PIK3CG | |
| SCHEMBL15286489 | 0.73 | RAB9A (0.49) | KDM4EUSP2ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL9537766 | 0.73 | NPC1 (0.61) | KDM4EALOX15HSD17B10ALDH1A1PLAU | |
| Oxalic Acid SCHEMBL9536045 | 0.73 | USP2 (0.57) | KDM4EUSP2ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL4523767 | 0.72 | PIK3CG (0.83) | KDM4EHSD17B10ALDH1A1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |