Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HNF4A | P41235 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27550 | 0.87 | CYP1A2 (0.54) | ACP3MTNR1ATDP1NQO2CYP1A2 | |
| SCHEMBL5250295 | 0.79 | ACP3 (0.49) | ACP3MTNR1ATDP1ALDH1A1NQO2 | |
| SCHEMBL2312926 | 0.77 | HPRT1 (0.54) | ACP3MTNR1ATDP1ALDH1A1CYP1A2 | |
| Nitric Acid SCHEMBL9873962 | 0.77 | ALDH1A1 (0.63) | TDP1ALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL2312666 | 0.77 | HPRT1 (0.54) | ACP3MTNR1ATDP1ALDH1A1CYP1A2 | |
| SCHEMBL80656 | 0.76 | MTNR1A (0.50) | ACP3MTNR1ATDP1ALDH1A1NQO2 | |
| SCHEMBL31131331 | 0.76 | MTNR1A (0.50) | ACP3MTNR1ATDP1ALDH1A1NQO2 | |
| Tetrahydrofuran SCHEMBL971564 | 0.75 | KCNA5 (0.46) | ACP3MTNR1ATDP1CYP1A2CYP2C9 | |
| SCHEMBL8957420 | 0.75 | NQO2 (0.46) | ACP3MTNR1ATDP1ALDH1A1NQO2 | |
| SCHEMBL3047898 | 0.74 | CYP1A2 (0.62) | ACP3MTNR1ATDP1ALDH1A1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | claimed |
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |