SCHEMBL9715643

SCHEMBL9715643

CCOc1ccc(OC)c(OC)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.64
CA12 O43570 1/20 0.64
CA1 P00915 1/20 0.64
CA7 P43166 1/20 0.64
CA9 Q16790 1/20 0.64
CA14 Q9ULX7 1/20 0.64
HIF1A Q16665 1/20 0.57
NQO1 P15559 1/20 0.54
KDM4E B2RXH2 4/20 0.53
MAPT P10636 3/20 0.53
GAA P10253 2/20 0.53
MAPK1 P28482 1/20 0.51
LMNA P02545 4/20 0.51
TUBB4A P04350 1/20 0.50
TUBB P07437 1/20 0.50
TUBA3C P0DPH7 1/20 0.50
TUBA1B P68363 1/20 0.50
TUBA4A P68366 1/20 0.50
TUBB4B P68371 1/20 0.50
TUBB3 Q13509 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19612211 0.94 KDM4E (0.61) CA2CA12CA1CA7CA9
SCHEMBL28891596 0.87 KDM4E (0.50) CA2CA12CA1CA7CA9
SCHEMBL12093645 0.85 CA12 (0.68) CA2CA12CA1CA7CA9
SCHEMBL8888440 0.85 CA12 (0.68) CA2CA12CA1CA7CA9
SCHEMBL27799760 0.84 CA2 (0.55) CA2CA12CA1CA7CA9
SCHEMBL7013648 0.84 HIF1A (0.49) CA2CA12CA1CA7CA9
SCHEMBL7013645 0.84 HIF1A (0.49) CA2CA12CA1CA7CA9
SCHEMBL16953203 0.83 ALDH1A1 (0.56) CA2CA12CA1CA7CA9
SCHEMBL15450963 0.83 CA2 (0.59) CA2CA12CA1CA7CA9
SCHEMBL13256249 0.83 NQO1 (0.50) CA2CA12CA1CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1863763-A Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion for the treatment of disease JOLLA PHARMA (US) 2006-11-15 CN disclosed
CN-1184423-A Nodulisporic acid derivatives MERCK & CO INC (US) 1998-06-10 CN disclosed
EP-0500530-A1 CATALYST COMPONENT FOR MAKING PRIMARILY ISOTACTIC ELASTOMERIC POLYPROPYLENE OR POLYBUTENE. SHELL OIL CO (US) 1992-09-02 EP disclosed
EP-0500530-A4 CATALYST COMPONENT FOR MAKING PRIMARILY ISOTACTIC ELASTOMERIC POLYPROPYLENE OR POLYBUTENE. SHELL OIL CO (US) 1992-05-14 EP disclosed
US-4029699-A CHOLERETIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) 1977-06-14 US disclosed
US-4017517-A SPASMOLYTIC, CHOLERETIC TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) 1977-04-12 US disclosed
US-3946040-A JUVENILE HORMONE ACTIVITY, INSECTICIDES HOFFMANN-LA ROCHE INC. (US) 1976-03-23 US disclosed
US-3943169-A DIURETIC, SPASMOLYTIC TAKEDA CHEMICAL INDUSTRIES, LTD (JA) 1976-03-09 US disclosed