SCHEMBL7013645

SCHEMBL7013645

CCOc1ccc(O[C]=O)c(OC)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.49
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
KDM4E B2RXH2 5/20 0.44
TSHR P16473 3/20 0.44
MAPT P10636 4/20 0.44
LMNA P02545 3/20 0.44
GAA P10253 1/20 0.44
MAPK1 P28482 2/20 0.43
KMT2A Q03164 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
NQO1 P15559 1/20 0.42
TUBB4A P04350 1/20 0.42
TUBB P07437 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1787478 0.86 KDM4E (0.50) HIF1ACA12CA1CA7CA9
SCHEMBL2089114 0.84 CA12 (0.65) CA12CA1CA2CA7CA9
SCHEMBL7203437 0.84 HIF1A (0.47) HIF1ACA12CA1CA2CA7
SCHEMBL9715643 0.84 CA2 (0.64) HIF1ACA12CA1CA2CA7
SCHEMBL19612211 0.82 KDM4E (0.61) HIF1ACA12CA1CA2CA7
SCHEMBL95360 0.78 CA2 (0.61) CA12CA1CA2CA7CA9
SCHEMBL7009749 0.78 KDM4E (0.45) HIF1AKDM4ETSHRMAPTLMNA
SCHEMBL2090982 0.77 CA12 (0.65) CA12CA1CA2CA7CA9
SCHEMBL7013648 0.77 HIF1A (0.49) HIF1ACA12CA1CA2CA7
SCHEMBL9098166 0.77 CA12 (0.42) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0815859-B1 INTIMAL THICKENING INHIBITORS TAIHO PHARMACEUTICAL CO LTD (JP) 2003-06-18 EP disclosed
US-RE38090-E1 Antitumor activity; useful for treatment and prevention of cancers Matsuda, Akira (JP) 2003-04-22 US disclosed
US-5977130-A CARDIOVASCULAR DISORDERS TAIHO PHARMEUTICAL CO., LTD. (JP) 1999-11-02 US disclosed
EP-0686641-B1 2'-DEOXY-5-FLUOROURIDINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PRODUCING THE SAME, AND ANTITUMOR DRUG TAIHO PHARMACEUTICAL CO LTD (JP) 1998-08-26 EP disclosed
US-5763418-A NUCLEOTIDE ANTITUMOR AGENTS Matsuda, Akira (JP) 1998-06-09 US disclosed
EP-0815859-A1 INTIMAL THICKENING INHIBITORS TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1998-01-07 EP disclosed
EP-0747389-A1 3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES TAIHO PHARMACEUTICAL CO., LTD. (JP) 1996-12-11 EP disclosed
EP-0686641-A1 2'-DEOXY-5-FLUOROURIDINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PRODUCING THE SAME, AND ANTITUMOR DRUG TAIHO PHARMACEUTICAL CO., LTD. (JP) 1995-12-13 EP disclosed