Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5360890 | 0.91 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL8273707 | 0.77 | PKM (0.45) | KDM4EALDH1A1HSD17B10LMNAPLK1 | |
| SCHEMBL25045981 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10LMNAPLK1 | |
| SCHEMBL30184719 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10LMNAPLK1 | |
| SCHEMBL5368137 | 0.77 | LCK (0.51) | KDM4EALDH1A1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL4467144 | 0.76 | KDM4E (0.73) | KDM4EALDH1A1HSD17B10LMNAPLK1 | |
| SCHEMBL23660879 | 0.76 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| Bifendate SCHEMBL29516235 | 0.75 | TARBP2 (0.48) | KDM4EALDH1A1HSD17B10LMNASMN1; SMN2 | |
| Bifendate SCHEMBL30788692 | 0.75 | TARBP2 (0.48) | KDM4EALDH1A1HSD17B10LMNASMN1; SMN2 | |
| Bifendate SCHEMBL896166 | 0.75 | TARBP2 (0.48) | KDM4EALDH1A1HSD17B10LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155111-A | Combined with 6-mercaptopurine | INSTITUTE OF MATERIA MEDICA (CN) | 1992-10-13 | — | — | US | disclosed |