Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.66 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716892 | 0.91 | REN (0.65) | REN | |
| SCHEMBL11013919 | 0.91 | REN (0.66) | RENCTSBCTSK | |
| SCHEMBL11010625 | 0.91 | REN (0.66) | RENCTSBCTSK | |
| SCHEMBL10724797 | 0.89 | REN (0.61) | REN | |
| SCHEMBL10724802 | 0.89 | REN (0.61) | REN | |
| SCHEMBL10723566 | 0.87 | REN (0.58) | REN | |
| SCHEMBL10723572 | 0.87 | REN (0.58) | REN | |
| SCHEMBL10720636 | 0.86 | REN (0.59) | REN | |
| SCHEMBL10720645 | 0.86 | REN (0.59) | REN | |
| SCHEMBL10723611 | 0.86 | REN (0.58) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077028-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1987-01-14 | — | — | EP | claimed |
| EP-0077028-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | claimed |
| EP-0498361-A2 | Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor | SCHERING CORPORATION (US) | 1992-08-12 | — | — | EP | disclosed |