Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.48 |
| ▸ | THRA | P10827 | 2/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11601438 | 0.86 | TSHR (0.61) | TSHRCYSLTR2CYSLTR1 | |
| SCHEMBL28470422 | 0.82 | TSHR (0.56) | TSHR | |
| SCHEMBL9717509 | 0.81 | FFAR4 (0.47) | THRBTHRALTB4RLTB4R2TSHR | |
| SCHEMBL11706103 | 0.80 | POLB (0.42) | FFAR4 | |
| SCHEMBL9717557 | 0.78 | THRB (0.64) | THRBTHRATSHRFFAR4CYSLTR2 | |
| SCHEMBL7813434 | 0.78 | HTT (0.60) | THRBLTB4RLTB4R2TSHR | |
| SCHEMBL28381703 | 0.77 | HTT (0.59) | THRBLTB4RLTB4R2TSHR | |
| SCHEMBL9717518 | 0.77 | THRB (0.62) | THRBTHRATSHRFFAR4CYSLTR2 | |
| SCHEMBL10636268 | 0.75 | LTB4R (0.52) | THRBTHRALTB4RLTB4R2CYSLTR2 | |
| SCHEMBL25168636 | 0.74 | LTB4R (0.77) | THRBTHRALTB4RLTB4R2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240256-B1 | COMPOUNDS USEFUL IN TREATING SICKLE CELL ANEMIA | MERCK & CO. INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4731473-A | Compounds useful in treating sickle cell anemia | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4731381-A | Method of treating a person for sickle cell anemia | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4699926-A | Compounds useful in treating sickle cell anemia | MERCK & CO., INC. (US) | 1987-10-13 | — | — | US | disclosed |
| EP-0240256-A2 | Compounds useful in treating sickle cell anemia | MERCK & CO. INC. (US) | 1987-10-07 | — | — | EP | disclosed |