Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TERT | O14746 | 6/20 | 0.44 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23214179 | 0.78 | TERT (0.52) | KDM4EALDH1A1CYP1A2TERTPIEZO1 | |
| SCHEMBL2160146 | 0.77 | KDM4E (0.51) | KDM4EALDH1A1CYP1A2TERTPIEZO1 | |
| SCHEMBL19336777 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1CYP1A2TERTPIEZO1 | |
| SCHEMBL971007 | 0.73 | KDM4E (0.74) | KDM4EALDH1A1CYP1A2HSD17B10HTT | |
| SCHEMBL17225689 | 0.73 | ALDH1A1 (0.52) | KDM4EALDH1A1CYP1A2TERTPIEZO1 | |
| SCHEMBL15399054 | 0.73 | TERT (0.48) | KDM4EALDH1A1CYP1A2TERTPIEZO1 | |
| SCHEMBL17225713 | 0.73 | ALDH1A1 (0.49) | KDM4EALDH1A1CYP1A2TERTPIEZO1 | |
| SCHEMBL8032949 | 0.72 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL12571314 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1CYP1A2TERTHSD17B10 | |
| SCHEMBL15398639 | 0.70 | KDM4E (0.50) | KDM4EALDH1A1CYP1A2TERTPIEZO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861367-A | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles or 2-mercapto-5-pyrazinyl-1,3,4-thiadiazoles as nematicides | CIBA-GEIGY CORPORATION (US) | 1989-08-29 | — | — | US | claimed |
| EP-0290379-A2 | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles and -1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-11-09 | — | — | EP | claimed |
| WO-2021067943-A1 | PIEZO1 AGONISTS FOR THE PROMOTION OF BONE FORMATION | BIOVENTURES, LLC (US) | 2021-04-08 | — | — | WO | disclosed |
| US-7871982-B2 | Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient | MEIJI SEIKA KAISHA, LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20090156512-A1 | potent activity against resistant pneumococci | MEIJI SEIKA KAISHA, LTD. (JP) | 2009-06-18 | — | — | US | disclosed |
| EP-1970377-A1 | LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2008-09-17 | — | — | EP | disclosed |
| US-4861367-A | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles or 2-mercapto-5-pyrazinyl-1,3,4-thiadiazoles as nematicides | CIBA-GEIGY CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |
| US-4861367-A | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles or 2-mercapto-5-pyrazinyl-1,3,4-thiadiazoles as nematicides | CIBA-GEIGY CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |
| US-4861367-A | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles or 2-mercapto-5-pyrazinyl-1,3,4-thiadiazoles as nematicides | CIBA-GEIGY CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0290379-A3 | 2-MERCAPTO-5-PYRAZINYL-1,3,4-OXADIAZOLES AND -1,3,4-THIADIAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS NEMATICIDAL AGENTS | CIBA-GEIGY AG (CH) | 1989-02-22 | — | — | EP | disclosed |
| EP-0290379-A2 | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles and -1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-11-09 | — | — | EP | disclosed |
| EP-0290379-A2 | 2-Mercapto-5-pyrazinyl-1,3,4-oxadiazoles and -1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156512-A1 | potent activity against resistant pneumococci | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NAT1, NPM1 | KDM4E 3077/4885ALDH1A1 2976/4885CYP1A2 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.