Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719015 | 0.82 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1KDM4ECNR2 | |
| SCHEMBL3007307 | 0.80 | L3MBTL1 (0.46) | KMT2AMEN1ALDH1A1KDM4ECNR2 | |
| SCHEMBL9719059 | 0.79 | ALDH1A1 (0.34) | KMT2AMEN1ALDH1A1KDM4ECNR2 | |
| SCHEMBL28484877 | 0.75 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1KDM4ECNR2 | |
| SCHEMBL3010010 | 0.68 | L3MBTL1 (0.46) | KMT2AMEN1ALDH1A1L3MBTL1GAA | |
| SCHEMBL16138748 | 0.68 | CCR1 (0.39) | KMT2AMEN1CNR2CCR1 | |
| SCHEMBL11436958 | 0.67 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1KDM4ECNR2 | |
| SCHEMBL622374 | 0.66 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1CNR2L3MBTL1 | |
| SCHEMBL3005304 | 0.65 | L3MBTL1 (0.48) | KMT2AMEN1ALDH1A1L3MBTL1GAA | |
| SCHEMBL22323105 | 0.65 | CCR1 (0.54) | KMT2AMEN1ALDH1A1CNR2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |