Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719059 | 0.86 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2MAPTRAB9AL3MBTL1 | |
| SCHEMBL9719050 | 0.82 | KMT2A (0.41) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL9719055 | 0.81 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTRAB9AL3MBTL1 | |
| SCHEMBL9719109 | 0.74 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MAPTRAB9AL3MBTL1 | |
| SCHEMBL9719027 | 0.71 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPTRAB9AL3MBTL1 | |
| SCHEMBL3007307 | 0.69 | L3MBTL1 (0.46) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MEN1 | |
| SCHEMBL28484877 | 0.66 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL9719008 | 0.65 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPTRAB9AL3MBTL1 | |
| SCHEMBL16751953 | 0.64 | CCR1 (0.37) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12428001 | 0.63 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2MAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |