Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9719242 | 0.90 | TDP1 (0.44) | TDP1TSHRMAPTMEN1THRB | |
| SCHEMBL1393746 | 0.87 | TSHR (0.55) | TDP1TSHRMAPTMEN1THRB | |
| Di(Hydroxyethyl)Ether SCHEMBL5694621 | 0.87 | TSHR (0.55) | TDP1TSHRMAPTMEN1THRB | |
| Butoxyethanol SCHEMBL491444 | 0.85 | TSHR (0.57) | TDP1TSHRMAPTMEN1THRB | |
| Malic Acid SCHEMBL9615895 | 0.85 | TDP1 (0.40) | TDP1TSHRMAPTMEN1THRB | |
| SCHEMBL56119 | 0.84 | TDP1 (0.58) | TDP1TSHRMAPTMEN1THRB | |
| Acrylic Acid SCHEMBL8850341 | 0.83 | TDP1 (0.41) | TDP1TSHRMEN1KMT2AHSD17B10 | |
| Acrylic Acid SCHEMBL8850928 | 0.83 | TDP1 (0.41) | TDP1TSHRMEN1KMT2AHSD17B10 | |
| Acrylic Acid SCHEMBL8850875 | 0.83 | TDP1 (0.41) | TDP1TSHRMEN1KMT2AHSD17B10 | |
| Acetic Acid SCHEMBL27976204 | 0.83 | TDP1 (0.49) | TDP1TSHRMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162402-A | For concrete containing a polymeric composition | SANDOZ LTD. (CH) | 1992-11-10 | — | — | US | disclosed |